Fig. 2

Selected miRNA-target pairs in the striatum of Hdh mice. a Shown are the 31 miRAMINT miRNA-target pairs (see also Table S3 for the full list of miRAMINT miRNA-target pairs in striatum). The targets are contained in rectangles and the miRNAs in ellipses. A thick edge means that evidence for binding sites is available from at least two miRNA databases. A thin edge means that evidence for binding sites is available from only one miRNA database. A thick rectangle means that the maximal LFC of the target is greater than 0.5. A cross arrow indicates the miRNA that is best paired with a target when this target has several possible miRNA regulators. Biological annotations of miRNA targets correspond to GO Biological processes or KEGG pathways at the result of STRING analyzes using stringent criteria (i.e. STRING score > 0.7, Databases and Experiments only, 20 neighbors added on the first shell) the KEGG pathways are those with, at least, 3 genes implied, the GO Biological processes are those with, at least, 5 genes implied. b Examples of 3D-graphs for top miRNA-target pairs (LFC amplitude of the target above 0.5)