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Table 1 Advantages and disadvantages of several constraint-based and ODE-based models

From: LK-DFBA: a linear programming-based modeling strategy for capturing dynamics and metabolite-dependent regulation in metabolism

MethodAdvantagesDisadvantages
FBAEfficient to solve for steady-state fluxes; many metabolic engineering tools built around FBACannot track metabolite dynamics
ODE-based modelsAble to track metabolite dynamics; accurately model reaction kineticsAbundant kinetic parameters; difficult to scale up to large systems
DFBA (DOA)Able to track metabolite dynamics; does not require complex kinetic equations for each fluxContains non-linear constraints that can make the optimization problem difficult to solve
DFBA (SOA)Able to track metabolite dynamics; does not require non-linear constraintsCannot incorporate kinetic or regulatory information