Fig. 5

Sub-clustering results produced by GOMCL-sub on cluster C1 described in Fig. 1. a Similarity heatmap of sub-groups identified by GOMCL-sub. b and c GO hierarchical structures of C1–1 and C1–2 sub-clusters. The black edges connect parent and child terms that are directly linked, while the grey edges indicate connections with intermediate GO terms between the parent and child terms. Node size represents the number of genes in the test set which are annotated to that GO term; and shade of each node represents p-value assigned by the enrichment test. Lighter to darker shades indicate larger to smaller p-values, respectively. The main hierarchical branches are marked by red circles