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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Prediction model construction of mouse stem cell pluripotency using CpG and non-CpG DNA methylation markers

Fig. 1

Overview of epigenetic and transcriptomic analysis of single stem cells for pluripotency prediction. In total, 75 mouse single embryonic stem cells (GSE74535), for which gene expression and DNA methylation were sequenced simultaneously, were used to generate a linear model that predicts cell pluripotency. The biological pseudo-time of each cell was determined using gene expression data. Using the CpG and non-CpG DNA methylation levels of each genomic interval, we constructed a linear model that predicts cell pseudo-time. Validation was performed using DNA methylation sequencing data from 34 independent samples of single and bulk ESCs (GSE56879)

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BMC Bioinformatics

ISSN: 1471-2105

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