Fig. 5

Prediction of cell pseudo-time via CpG and non-CpG methylation levels. (a-c). Correlation scatter plot of comparisons between cell pseudo-time and predicted cell time. In (a) and (b), each model used features that included a single cytosine type, CpG or non-CpG, respectively. In c, the model used a combination of markers for CpG and non-CpG sites. The fitted red lines represent a least-squares line for each scatter plot. R represents Pearson’s correlation coefficients, and m indicates the slopes of fitted linear lines. RMSE represents the root mean squared error between cell pseudo-time and predicted pseudo-time. (d-f) Receiver operating characteristic curves for classification of cells grown in 2i media or serum for the CpG, non-CpG, and combined models, respectively