Fig. 10

Interaction patterns presented in the context of protein structures. a Graph 0, containing F4, is represented in the structure of Bcl-xL-Bak peptide complex (PDB id 1BXL). Residues in gray represent protease residues and the ones in orange represent inhibitor residues. Oxygen and nitrogen atoms are shown in red and blue respectively. Residue L0 from motif LXXXXD in BH3 pro-apoptosis regulator Bak is shown here as LEU578 (b) Graph 39, containing F5, is represented above in the crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL (PDB id 4A1U). Salt bridges are depicted in green, hydrogen bonds in orange, and repulsive interactions in light yellow. Red dashed lines represent edges where interactions are described both as hydrogen bonds and salt bridges. Residue at position D+5 is highlighted here as ASP121