Fig. 13

The largest IPA gene network corresponding to the largest gene cluster of MTM for the breast cancer dataset. Red/Green denote genes which have increased/decreased expression among relapsing patients compared with non-relapsing patients. Solid/Dashed lines denote direct/indirect interactions. Genes highlighted with magenta borders are identified with cellular development, cellular growth, and cell cycle functions. ESR1 and CCND1 seem to be interacting with each other as well as many other genes whose interactions are affected in breast cancer. The faded colors denote smaller fold changes. As many genes involved in breast cancer relapse are heterogeneous with a small sub-population heavily affected, fold changes might fail to grasp the extent of the gene effect