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Table 2 Comparison of features for detecting diagnostic characters between DeSignate, BOLD’s Diagnostic Characters workbench utility [12], CAOS [13], and QUIDDICH [14]

From: DeSignate: detecting signature characters in gene sequence alignments for taxon diagnoses

FeaturesDeSignateBOLDCAOSQUIDDICH
Web interface++
Command-line interface+++
Open source license++
Requires no editing of input files+++
Free choice of nucleotide sequence alignment++++
Group selection with a (guide) tree++
Free choice of the query and reference groups+++
Analysis of combined characters++
Support for interpretation and validation+