Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes

Table 2 Homogenous clusters formed using DBSCAN on the first two principal components, following labeling with pathotype

Protein group	Protein count	Cluster count	V-measure
Fimbriae assembly proteins	24	2	0.47
Metabolism - All metabolic proteins	1515	2	0.44
COG Q (Secondary metabolites biosynthesis)	41	4	0.44
COG N (Cell motility)	27	3	0.41
Metabolism - Alternate carbon metabolism	231	3	0.39
Iron-sulfur-binding enzymes	118	2	0.38
Zinc-binding enzymes	125	3	0.37
All periplasmic proteins	315	2	0.37
All metal-binding proteins	590	3	0.33
Molybdenum-binding enzymes	14	2	0.31

For pathotypes, ExPEC/AIEC/APEC strains are grouped together as they likely encounter oxidative environments more frequently [50]. If a pathotype is unavailable for a strain, it was excluded from the homogeneity measurements.

ISSN: 1471-2105