Fig. 1

ceRNA interaction network. Figure shows ceRNA network interaction. The triangle represents the crosstalk of different ceRNA molecules. RNA molecules showed in each vertex of the triangle are different RNA molecules involved in ceRNA crosstalk. mRNA (ceRNA-A) interact with miRNAs trough MRE binding sites, and its expression is inhibited by miRNA linkage. miRNA can be also regulated himself by interacting with other ceRNA molecules (ceRNA-B) (lncRNAs, pseudogenes, mRNAs), by MRE site interaction with their seed sequence. ceRNA crosstalk is also influenced by the expression level of all RNA molecules that take part in the network. The functional balance of gene network in a specific cell or tissue is due to transcriptional levels of ceRNA-A and ceRNA-B molecules, and they behave like "competitors" for the same miRNA cluster