Table 1 Simulation experiments description
From: SCeQTL: an R package for identifying eQTL from single-cell parallel sequencing data
SNVs | Experiments | Unchanged parameters | Changed parameters | Number of experiments | |
|---|---|---|---|---|---|
SNV 1 (freq. of s = 0/1/2: 0.25/0.5/ 0.25) | Experiment 1 | Zero ratios set to the same (0.5). Differences in NB means among three genotypes increase. | α1 = 0 | β2 ranges from 0 to 0.6, with increasing step of 0.05 across experiments. | 13 |
β1 = 0 | |||||
α2 = 6 | |||||
Experiment 2 | Zero ratios set at different levels (0.5, 0.57 and 0.65). Differences in NB means among three genotypes increase. | α1 = 0 | 13 | ||
β1 = 0.3 | |||||
α2 = 6 | |||||
Experiment 3 | NB means set at the same level (403.43). Differences in zero ratios among three genotypes increase. | α2 = 6 | β1 ranges from 0 to 0.6, with increasing step of 0.05 across experiments. | 13 | |
β2 = 0 | |||||
α1 = 0 | |||||
Experiment 4 | NB means set at different levels (403.43, 601.85 and 897.85). Differences in zero ratios among three genotypes increase. | α2 = 6 | 13 | ||
β2 = 0.4 | |||||
α1 = 0 | |||||
SNV 2 (0.16/0.48/0.36) | Same as in SNV 1 | ||||
SNV 3 (0.09/0.42/0.49) | Same as in SNV 1 | ||||