Table 4 Real data: MWSL estimation comparison between the permutation method and the approximation procedure generating the distribution of the minimum p value as a Beta(1,MeffMWSL)
From: Multiple-testing correction in metabolome-wide association studies
MESA BINNED | MESA NOESY | MESA CPMG | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Beta(1,345) | Permutation | Â | Beta(1,1931) | Permutation | Â | Beta(1,11570) | Permutation |
ENT/ANT(%) | 51.4% | 53.8% | ENT/ANT(%) | 6.2% | 9.0% | ENT/ANT(%) | 36.9% | 52.3% |
ENT | 336 | 352 | ENT | 1883 | 2744 | ENT | 11279 | 16014 |
ENT_CI.low | 335 | 338 | ENT_CI.low | 1874 | 2439 | ENT_CI.low | 11229 | 14509 |
ENT_CI.up | 338 | 369 | ENT_CI.up | 1891 | 3080 | ENT_CI.up | 11330 | 17208 |
MWSL | 0.0001486 | 0.0001410 | MWSL | 0.0000266 | 0.0000179 | MWSL | 0.0000044 | 0.0000031 |
MWSL_CI.up | 0.0001493 | 0.0001476 | MWSL_CI.up | 0.0000267 | 0.0000195 | MWSL_CI.up | 0.0000045 | 0.0000036 |
MWSL_CI.low | 0.0001480 | 0.0001340 | MWSL_CI.low | 0.0000264 | 0.0000160 | MWSL_CI.low | 0.0000044 | 0.0000028 |