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Table 4 Real data: MWSL estimation comparison between the permutation method and the approximation procedure generating the distribution of the minimum p value as a Beta(1,MeffMWSL)

From: Multiple-testing correction in metabolome-wide association studies

MESA BINNED MESA NOESY MESA CPMG
  Beta(1,345) Permutation   Beta(1,1931) Permutation   Beta(1,11570) Permutation
ENT/ANT(%) 51.4% 53.8% ENT/ANT(%) 6.2% 9.0% ENT/ANT(%) 36.9% 52.3%
ENT 336 352 ENT 1883 2744 ENT 11279 16014
ENT_CI.low 335 338 ENT_CI.low 1874 2439 ENT_CI.low 11229 14509
ENT_CI.up 338 369 ENT_CI.up 1891 3080 ENT_CI.up 11330 17208
MWSL 0.0001486 0.0001410 MWSL 0.0000266 0.0000179 MWSL 0.0000044 0.0000031
MWSL_CI.up 0.0001493 0.0001476 MWSL_CI.up 0.0000267 0.0000195 MWSL_CI.up 0.0000045 0.0000036
MWSL_CI.low 0.0001480 0.0001340 MWSL_CI.low 0.0000264 0.0000160 MWSL_CI.low 0.0000044 0.0000028