Fig. 3

Monocarboxylate Transporter Expression in Glioblastoma. For glioblastoma tumors PJ025 from Yuan et al. [28] (a) and MGH125 from Neftel et al. [19] (b), we used CHARTS to visualize the expression of MCT4 (gene symbol “SLC16A3” in the CHARTS application), the expression of MCT1 (gene symbol “SLC16A1” in the CHARTS application), malignancy score, the probability that each cell is a myeloid cell, and each cell’s enrichment score for genes in the Hallmark hypoxia gene set as produced by GSVA. (C) A schematic illustration of the metabolic symbiosis between hypoxic, glycolytic tumor cells expressing MCT4 and oxidative tumor cells expressing MCT1