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Table 6 Results from likelihood ratio tests applied on the top four ranked interactions found from the model explainability process based on the evaluation data

From: A new method for exploring gene–gene and gene–environment interactions in GWAS with tree ensemble methods and SHAP values

Data set

Interaction

p-value LRT

Evaluation data

rs171329 and rs180743

0.85

All individuals

rs171329 and rs180743

0.024

Evaluation data

rs17817449 and genetic sex

0.77

All individuals

rs17817449 and genetic sex

4.09e-05

Evaluation data

rs17817449 and saturated fat intake

0.44

All individuals

rs17817449 and saturated fat intake

0.0017

Evaluation data

rs757318 and rs12123815

0.25

All individuals

rs757318 and rs12123815

0.71