Fig. 6

Inspection of trends in SARS-CoV-2 proteomics and transcriptomics datasets. Statistical analysis performed using the following settings: FDR < 0.05 and log2 fold change > 0.3. For both datasets, data from 24 h after viral infection are used a Inspection of infected samples, 10 h and 24 h compared to 2 h, colored by proteins known as virus proteins (‘virus’ in blue) and virus receptors (‘virus_host’ in green) revealed a clear upregulation among virus proteins. b Direct comparison of infected and control at 24 h after infection in proteomics and comparison between the proteomic dataset and the transcriptomic dataset (expansion media). The coloring is based on in which dataset the gene products pass the significance threshold. Green points (“contra” in the legend) are passing the significance threshold in both datasets, but with reversed log2 fold direction. This comparison revealed a set of shared proteins, both changing abundance in the same or opposite direction. c Illustration of the shared significant genes between proteomic (“prot”) and transcriptomic (differential “diff” and expansion “exp” media) datasets. d CD47 distribution at different time points in the proteomic study and in the transcriptomic data