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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Dualmarker: a flexible toolset for exploratory analysis of combinatorial dual biomarkers for clinical efficacy

Fig. 3

Demonstration of survival analysis for one pair of markers, ARID1A mutation (marker1) and CXCL13 gene expression (marker2). KM plot of a single marker for mut_ARID1A (a) and CXCL13 expression (cut by median, b) and the dual markers (c). Four group sizes and independence tests using Fisher’s exact test (d), the median survival time and confidence interval in each group/quadrant are shown in a matrix (e) and line chart (f). Conditional KM plots show the survival curves of marker2 stratified by the marker1 level (g, upper panel) as well as marker1 within the context of the marker2 level (g, lower 2 panel) with the p values of log-rank test and adjusted p values by ‘Bonferroni’ method. All figures were generated by dualmarker (v0.1.0)

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BMC Bioinformatics

ISSN: 1471-2105

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