Table 1 Previously known condition-associated CDR3s in the list of DA enriched CDR3s identified by the method (using randomization test)
Dataset | known condition-associated CDR3s in all samples (*likely CD4, CD8) | Feature space | Known condition-associated CDR3s in DA enriched (likely CD4, CD8) | Permutation test p value (CD4, CD8) |
|---|---|---|---|---|
CD PBMC | 56 (20, 36) | nt 4-mer | 14 (9, 3) | p = 0.0 (0.0, 0.09) |
CD PBMC | 56 (20, 36) | aa 3-mer | 10 (7, 2) | p = 0.0 (0.0, 0.33) |
CD GUT | 50 (23, 24) | nt 4-mer | 3 (0, 3) | p = 0.48 (1, 0.05) |
CD GUT | 50 (23, 24) | aa 3-mer | 5 (1, 4) | p = 0.13 (0.85, 0.02) |
YFV PBMC | 12,092 | nt 4-mer | 697 | p = 0.0 |
Twin YFV PBMC | 5730 | nt 4-mer | 2058 | p = 0.0 |