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Table 1 Previously known condition-associated CDR3s in the list of DA enriched CDR3s identified by the method (using randomization test)

From: Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences

Dataset known condition-associated CDR3s in all samples (*likely CD4, CD8) Feature space Known condition-associated CDR3s in DA enriched (likely CD4, CD8) Permutation test p value (CD4, CD8)
CD PBMC 56 (20, 36) nt 4-mer 14 (9, 3) p = 0.0 (0.0, 0.09)
CD PBMC 56 (20, 36) aa 3-mer 10 (7, 2) p = 0.0 (0.0, 0.33)
CD GUT 50 (23, 24) nt 4-mer 3 (0, 3) p = 0.48 (1, 0.05)
CD GUT 50 (23, 24) aa 3-mer 5 (1, 4) p = 0.13 (0.85, 0.02)
YFV PBMC 12,092 nt 4-mer 697 p = 0.0
Twin YFV PBMC 5730 nt 4-mer 2058 p = 0.0
  1. *Previously reported CD associated CDR3s are assumed likely CD4 and CD8 based on their reported CD4 and CD8 status in the papers they were reported. For some such information was not available
  2. p values show non-significant results
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