Fig. 2From: Deciphering hierarchical organization of topologically associated domains through change-point testingSchematic plot of hierarchical TAD detection. a Block diagonal with K change-points and one change-point (red region). Sub-matrices are shown with a red region that has a single change-point. b The bottom-up procedure for detecting hierarchical TADs. At each iteration, the p values are iteratively calculated for all boundaries, and the layer labels of inner boundaries of two blocks are iteratively updated if they satisfy merge conditionsBack to article page