Fig. 5

Module 3: phenotype discovery. a Overview of this module. In step 1, ROIs from all variants were pooled and their feature maps extracted. In step 2 (see Fig. 6), clustering algorithm grouped ROIs with similar features together. b Details of the feature extraction process. Each ROIs was processed through a reconfigured and pretrained VGG-16, resulting in a feature map containing 8192 features. c 16 of the 128 convolutional filters from the first layer of the second convolutional block of VGG-16. d 16 intermediate feature maps extracted by the convolutional filters in c