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Table 1 Number of TFs, TGs and TFBS obtained from different TFBS identification algorithms for GM12878 and K562 cell lines

From: Modeling transcriptional regulation using gene regulatory networks based on multi-omics data sources

 

GM12878

K562

TFs

TGs

TFBS

Unique TF-TG Pairs

TFs

TGs

TFBS

Unique TF-TG Pairs

Pos ChIP-Seq

149

17,106

4,209,133

1,216,272

309

18,190

11,614,248

2,372,274

FIMO

85

16,850

2,444,195

714,167

110

18,173

7,349,429

1,138,823

TEPIC

80

11,784

517,226

86

10,239

880,554

Promoter

149

11,509

458,959

276,138

308

15,668

1,293,933

681,847

Distal

149

16,964

3,750,174

1,128,079

309

18,152

10,320,315

2,312,490

Intronic

149

17,106

5,896,338

1,378,129

309

18,224

14,764,766

2,820,604

  1. The “Pos ChIP-Seq” row contains TFBS identified by simply extracting the TF peaks in the cis regulatory regions around each gene, “FIMO” row contains statistically significant positional TFBS identified using the FIMO algorithm and the TEPIC row contains positional TFBS extracted based on the TEPIC affinity scores. The remaining rows contain the positional TFBS present within different regulatory elements utilized for the subsequent analyses in the paper. All the ChIP-seq data for the analysis was downloaded from the ENCODE database