Genome-wide variant-based study of genetic effects with the largest neuroanatomic coverage

BMC Bioinformatics

Table 1 Eight significant SNPs, SNP pair and SNP sets identified in VBC, VBP, RBC, RBP, AR and SR

NO.	SNP	Gene	CHR	Explained variance	Pearson correlation
NO.	SNP	Gene	CHR	(R square)	Hippocampus	Memories	Memory
1	rs6092321	RTF2	20	0.009303	0.073	0.0806	0.0042
2	rs6024860		20	0.008197	0.0198	0.075	0.0354
3	rs6092321-	RTF2	20	0.00939	0.0945	0.0533	− 0.0381
	rs700319	CNTNAP2	7
4	rs6092321-	RTF2	7	0.009825	0.0804	0.0675	− 0.0111
	rs10500192-	CNTNAP2	7
	rs4811693	FAM210B	20
5	rs429358-	APOE	19	0.0112	0.3034	0.1542	0.1274
	rs2640726-	EPHX2	8
	rs4621717	CNTNAP2	7
6	rs429358-	APOE	19	0.0112	0.3094	0.1463	0.1198
	rs516125-	SCARA3	8
	rs4621717	CNTNAP2	7
7	rs429358-	APOE	19	0.0113	0.3098	0.147	0.116
	rs10933428-	INPP5D	2
	rs4621717	CNTNAP2	7
8	rs429358-	APOE	19	0.0117	0.3085	0.1522	0.1186
	rs12539907-	CNTNAP2	7
	rs4621717	CNTNAP2	7

Explained variance = For 1, 2, 3 and 4, explained variance of whole brain; for 5, 6, 7 and 8, explained variance of hippocampus; Pearson correlation = the association between SNPs, SNP pair or SNP sets and features; Hippocampus, Memories and Memory = the part of features associated with Alzheimer’s disease

ISSN: 1471-2105