Table 6 Results of external validation on CCLE and CTRP

17-AAG(CCLE)

0.682

0.666

0.628

0.656

0.678

0.669

0.481

0.530

0.717

Afatinib(CTRP)

0.798

0.783

0.771

0.788

0.776

0.794

0.605

0.541

0.793

Axitinib(CTRP)

0.795

0.777

0.795

0.761

0.752

0.796

0.631

0.521

0.794

AZD7762(CTRP)

0.797

0.785

0.777

0.762

0.794

0.800

0.681

0.526

0.746

AZD8055(CTRP)

0.679

0.693

0.698

0.659

0.688

0.680

0.622

0.508

0.693

BI-2536(CTRP)

0.510

0.526

0.473

0.510

0.547

0.507

0.487

0.632

0.678

Bleomycin(CTRP)

0.631

0.602

0.569

0.614

0.605

0.632

0.594

0.500

0.574

BMS-345541(CTRP)

0.740

0.756

0.759

0.716

0.721

0.757

0.606

0.756

0.756

BMS-754807(CTRP)

0.671

0.665

0.691

0.649

0.662

0.677

0.510

0.666

0.690

Bortezomib(CTRP)

0.283

0.274

0.258

0.287

0.333

0.250

0.465

0.489

0.751

Bosutinib(CTRP)

0.794

0.778

0.773

0.760

0.730

0.791

0.624

0.688

0.727

CAL-101(CTRP)

0.772

0.748

0.748

0.724

0.734

0.764

0.642

0.751

0.748

Crizotinib(CCLE)

0.718

0.717

0.625

0.715

0.735

0.706

0.586

0.673

0.773

Cytarabine(CTRP)

0.831

0.810

0.830

0.781

0.809

0.834

0.713

0.739

0.845

Dabrafenib(CTRP)

0.840

0.824

0.832

0.810

0.821

0.838

0.755

0.886

0.785

Dasatinib(CTRP)

0.669

0.664

0.633

0.669

0.647

0.660

0.519

0.660

0.639

Docetaxel(CTRP)

0.469

0.412

0.354

0.450

0.476

0.458

0.497

0.412

0.538

Doxorubicin(CTRP)

0.669

0.634

0.606

0.555

0.654

0.655

0.631

0.532

0.563

Erlotinib(CCLE)

0.698

0.665

0.704

0.667

0.680

0.702

0.525

0.555

0.722

Etoposide(CTRP)

0.824

0.813

0.827

0.731

0.770

0.826

0.690

0.736

0.719

EX-527(CTRP)

0.739

0.706

0.721

0.700

0.774

0.724

0.570

0.764

0.747

GDC0941(CTRP)

0.704

0.702

0.727

0.693

0.723

0.699

0.618

0.651

0.648

Gefitinib(CTRP)

0.690

0.683

0.684

0.656

0.675

0.692

0.562

0.649

0.698

Gemcitabine(CTRP)

0.614

0.598

0.671

0.557

0.583

0.644

0.655

0.523

0.562

GW843682X(CTRP)

0.454

0.534

0.413

0.483

0.582

0.469

0.486

0.576

0.660

Imatinib(CTRP)

0.682

0.679

0.648

0.690

0.698

0.691

0.549

0.596

0.791

JNJ-26854165(CTRP)

0.740

0.707

0.698

0.650

0.745

0.739

0.701

0.671

0.667

KU-55933(CTRP)

0.653

0.661

0.646

0.650

0.647

0.665

0.544

0.665

0.639

Lapatinib(CTRP)

0.661

0.638

0.692

0.662

0.610

0.656

0.548

0.588

0.688

Masitinib(CTRP)

0.820

0.813

0.816

0.821

0.809

0.822

0.721

0.807

0.815

Methotrexate(CTRP)

0.729

0.722

0.724

0.730

0.699

0.746

0.535

0.684

0.762

MG-132(CTRP)

0.374

0.433

0.355

0.403

0.372

0.363

0.626

0.492

0.641

Mitomycin C(CTRP)

0.707

0.655

0.627

0.593

0.662

0.699

0.584

0.526

0.627

MK-2206(CTRP)

0.733

0.733

0.710

0.717

0.742

0.733

0.642

0.754

0.753

Nilotinib(CCLE)

0.616

0.577

0.638

0.583

0.601

0.613

0.535

0.675

0.683

Nutlin-3a(CCLE)

0.928

0.906

0.868

0.910

0.938

0.908

0.906

0.928

0.902

NVP-BEZ235(CTRP)

0.636

0.584

0.543

0.607

0.583

0.626

0.576

0.512

0.616

NVP-TAE684(CTRP)

0.535

0.571

0.494

0.538

0.540

0.525

0.474

0.505

0.666

Obatoclax Mesylate(CTRP)

0.672

0.613

0.618

0.607

0.671

0.666

0.619

0.611

0.644

OSI-027(CTRP)

0.701

0.690

0.698

0.674

0.688

0.702

0.610

0.684

0.646

OSI-930(CTRP)

0.808

0.795

0.806

0.819

0.773

0.824

0.740

0.747

0.829

PAC-1(CTRP)

0.734

0.660

0.706

0.661

0.729

0.713

0.706

0.812

0.760

Paclitaxel(CTRP)

0.449

0.405

0.352

0.436

0.414

0.343

0.453

0.547

0.722

Parthenolide(CTRP)

0.623

0.642

0.546

0.616

0.592

0.580

0.601

0.609

0.708

Pazopanib(CTRP)

0.680

0.635

0.616

0.659

0.631

0.661

0.602

0.651

0.679

PD-0325901(CCLE)

0.854

0.841

0.843

0.821

0.840

0.852

0.635

0.828

0.826

PD-0332991(CCLE)

0.645

0.609

0.678

0.552

0.651

0.645

0.680

0.676

0.629

PHA-665752(CCLE)

0.524

0.553

0.487

0.535

0.527

0.534

0.504

0.495

0.612

PHA-793887(CTRP)

0.822

0.808

0.835

0.818

0.815

0.813

0.720

0.798

0.826

PI-103(CTRP)

0.785

0.759

0.758

0.742

0.734

0.751

0.643

0.750

0.781

PIK-93(CTRP)

0.817

0.821

0.826

0.807

0.828

0.820

0.718

0.844

0.814

piperlongumine(CTRP)

0.727

0.639

0.682

0.627

0.657

0.740

0.658

0.616

0.585

PLX4720(CCLE)

0.875

0.873

0.871

0.839

0.868

0.884

0.640

0.781

0.870

Ruxolitinib(CTRP)

0.763

0.756

0.775

0.745

0.744

0.773

0.619

0.769

0.777

SN-38(CTRP)

0.735

0.730

0.717

0.675

0.749

0.721

0.620

0.742

0.776

SNX-2112(CTRP)

0.800

0.789

0.782

0.740

0.793

0.779

0.633

0.759

0.672

Sorafenib(CCLE)

0.552

0.633

0.555

0.666

0.623

0.627

0.576

0.595

0.773

Sunitinib(CTRP)

0.552

0.642

0.578

0.628

0.591

0.570

0.589

0.580

0.755

Tamoxifen(CTRP)

0.617

0.630

0.591

0.619

0.575

0.632

0.516

0.609

0.701

Temozolomide(CTRP)

0.834

0.827

0.820

0.826

0.818

0.825

0.609

0.771

0.794

Temsirolimus(CTRP)

0.731

0.692

0.689

0.654

0.679

0.726

0.688

0.762

0.748

TG101348(CTRP)

0.771

0.786

0.803

0.754

0.774

0.770

0.696

0.790

0.781

TGX221(CTRP)

0.461

0.421

0.414

0.544

0.455

0.476

0.434

0.646

0.646

TPCA-1(CTRP)

0.784

0.779

0.788

0.778

0.795

0.777

0.668

0.793

0.795

Trametinib(CTRP)

0.772

0.783

0.746

0.772

0.770

0.761

0.597

0.717

0.773

Tubastatin A(CTRP)

0.870

0.866

0.888

0.865

0.865

0.872

0.739

0.895

0.878

TW 37(CTRP)

0.599

0.444

0.504

0.512

0.520

0.606

0.511

0.505

0.527

Vorinostat(CTRP)

0.793

0.820

0.847

0.776

0.749

0.799

0.619

0.826

0.745

VX-680(CTRP)

0.724

0.773

0.719

0.715

0.802

0.749

0.679

0.750

0.899

YK 4-279(CTRP)

0.786

0.763

0.785

0.759

0.765

0.800

0.574

0.628

0.747

YM155(CTRP)

0.662

0.591

0.602

0.601

0.513

0.507

0.481

0.505

0.632

ZSTK474(CTRP)

0.773

0.783

0.779

0.756

0.729

0.771

0.651

0.753

0.770

AVG

0.697

0.685

0.677

0.674

0.685

0.693

0.607

0.663

0.721