A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation

BMC Bioinformatics

Table 2 Markers of the phases of the cell cycle

Phase	Marker	Compartment
early G1	CCND1:CDK6(P@Thr):CDKN1B	Nucleoplasm
	pRB:E2F1:DP1:SWI:SNF:HDAC1	Nucleoplasm
	SWI:SNF:HDAC1:SUV39H1:pRB:E2F1:DP1	Nucleoplasm
	CCND1:CDK4(P@Thr172):CDKN1B	Nucleoplasm
	pRB:E2F1:DP1:SWI:SNF:HDAC1:SUV39H1:HP1gamma	Nucleoplasm
late G1	pRB(P):E2F1:DP1:SWI:SNF:HDAC1	Nucleoplasm
late G1	pRB(P\|P):E2F1:DP1:SWI:SNF	Nucleoplasm
early S	CCNE1:CDK2(P@Thr160)	Nucleoplasm
late S	CCNA2:CDK2(P@Thr160)	Nucleoplasm
G2	CCNB1:CDK1(P@Tyr15)	Cytoplasm
	CCNB1:CDK1(P@Tyr15\|P@Thr14)	Cytoplasm
	CCNB1:CDK1	Cytoplasm
	CCNB1:CDK1(P@Thr14)	Cytoplasm
M	CDC25(P)	Nucleoplasm
	WEE1(P@Ser53)	Nucleoplasm
	CCNB1:CDK1(P@Thr161)	Nucleoplasm
	CDC20(P)	Nucleoplasm

The markers for each phase of the cell cycle are given under a textual form. The names used to describe the markers are the labels of the corresponding entities in the map. Subunits in complexes are separated using the “:” character. Text in parantheses gives the post-translational modifications of a given entity (protein or complex subunit). For example, “P@Thr172” represents a phosphorylation at threonine 172. A same entity may have more than one post-translational modifications, separated in the text by the “|” character

ISSN: 1471-2105