Fig. 3

The integrated analysis and visualization of the transcriptional and epigenetic features of Tfap2c during the mouse germline cycle. A A line plot and heatmaps showing the integrated analysis of the transcriptional and epigenetic features of Tfap2c during mouse germline cycle. Breakpoints in the line plot indicate missing values at distinct developmental stages. Heatmaps represent the average DNA methylation levels, average chromatin accessibility signals, and histone modification features on the promoter of Tfap2c, while gradient color reflects the intensity of the signal, and white grids indicate missing values at distinct developmental stages. The overall PCCs between the expression levels with these features are displayed at the right of the heatmaps. B The overall continuous trends of the epigenetic features (H3K4me3 and H3K27me3) on the promoter of Tfap2c. Curves in each panel were fitted by quartic polynomial regression models. C A volcano plot showing the PCCs and the correlation test’s p-values of the transcriptional similarity between Tfap2c and other correlated changing genes