Fig. 6From: Identifying biomarkers for breast cancer by gene regulatory network rewiringThe framework of biomarker discovery based on network rewiring. a Reconstruct the disease and normal GRNs respectively by integrating prior background network and gene expression data. b Extract the rewiring regulations and establish a D-GRN. Module detection is implemented to find closely-connected nodes in D-GRN. c Identify biomarkers in each module through LR-RFEBack to article page