Table 2 The enriched GO biological processes of identified biomarkers in D-GRN

GO:0031323

Regulation of cellular metabolic process

1.90E−30

NFKB2, DGKZ, JUN, KLF9, RAD51, UHRF1, CDC25A, CCNE1, CDK2, CCNE2, TAF11, PKMYT1, ZBTB4, UBE2S, CDKN2C, KDM4B, BCL2, TCEAL5, NFYA, NR3C1, MAZ, MAFF, CTGF, KLF4, STAT5B, TP73, GATA3, HOXA10, SOX4, BRCA1

GO:0060255

Regulation of macromolecule metabolic process

7.40E−29

NFKB2, BAX, JUN, KLF9, RAD51, UHRF1, CCNE1, CDK2, TAF11, ZBTB4, UBE2S, KDM4B, BCL2, TCEAL5, NFYA, NR3C1, MAZ, MAFF, CTGF, KLF4, STAT5B, TP73, GATA3, HOXA10, SOX4, BRCA1

GO:0051171

Regulation of nitrogen compound metabolic process

4.00E−26

NFKB2, JUN, KLF9, RAD51, UHRF1, CCNE1, CDK2, TAF11, ZBTB4, KDM4B, TCEAL5, NFYA, NR3C1, MAZ, MAFF, KLF4, STAT5B, TP73, GATA3, HOXA10, SOX4, BRCA1

GO:0051726

Regulation of cell cycle

3.30E−24

DGKZ, JUN, CDC25A, CDK2, CCNE2, PKMYT1, CDKN2C, NEK2, TACC3, BCL2, CTGF, STAT5B, TP73, BRCA1

GO:0019219

Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

8.80E−24

NFKB2, JUN, KLF9, RAD51, UHRF1, CCNE1, CDK2, TAF11, ZBTB4, KDM4B, TCEAL5, NFYA, NR3C1, MAZ, MAFF, KLF4, STAT5B, TP73, GATA3, HOXA10, SOX4, BRCA1

GO:0010604

Positive Regulation of macromolecule metabolic process

1.10E−23

JUN, RAD51, CCNE1, CDK2, TAF11, UBE2S, BCL2, NFYA, CTGF, STAT5B, TP73, SOX4, BRCA1

GO:0051173

Positive regulation of nitrogen compound metabolic process

2.10E−23

JUN, RAD51, CCNE1, CDK2, TAF11, NFYA, STAT5B, TP73, SOX4, BRCA1

GO:0009893

Positive regulation of metabolic process

2.40E−23

JUN, RAD51, CCNE1, CDK2, TAF11, UBE2S, BCL2, NFYA, CTGF, STAT5B, TP73, SOX4, BRCA1

GO:0006357

Regulation of Transcription from RNA polymerase II promoter

1.00E−16

JUN, KLF9, UHRF1, NFYA, STAT5B, BRCA1

GO:0042127

Regulation of cell proliferation

1.20E−16

JUN, CDK2, CDKN2C, BCL2, CTGF, KLF4, STAT5B, SOX4, BRCA1

GO:0048545

Response to steroid hormone stimulus

5.60E−15

CCNE1, BCL2, CTGF, STAT5B, GATA3, BRCA1

GO:0051716

Cellular response to stimulus

1.70E−11

DGKZ, JUN, RAD51, UHRF1, CCNE1, POLE2, BCL2, PIK3R1, STAT5B, TP73, BRCA1

GO:0010941

Regulation of cell death

5.10E−10

BAX, JUN, TUBB, CDKN2C, BCL2, CTGF, STAT5B, TP73, SOX4, BRCA1

GO:0043067

Regulation of programmed cell death

1.70E−09

BAX, JUN, TUBB, CDKN2C, BCL2, CTGF, STAT5B, TP73, SOX4, BRCA1

GO:0042325

Regulation of Phosphorylation

6.80E−09

DGKZ, JUN, CDC25A, CCNE2, PKMYT1, CDKN2C, BCL2, CTGF, TP73

GO:0007346

Regulation of mitotic cell cycle

7.00E−09

DGKZ, CDK2, PKMYT1, NEK2, BCL2, STAT5B

GO:0051094

Positive regulation of developmental process

1.20E−08

BAX, JUN, CCNE1, BCL2, STAT5B

GO:0006974

Response to DNA damage stimulus

5.20E−07

DGKZ, RAD51, UHRF1, POLE2, TP73, BRCA1

GO:0000075

Cell cycle checkpoint

2.00E−06

DGKZ, CCNE2, BRCA1

GO:0045786

Negative regulation of cell cycle

2.60E−06

DGKZ, CDKN2C, BCL2, TP73

GO:0030522

Intracellular receptor mediated signaling pathway

2.90E−06

KLF9, CCNE1, BRCA1

GO:0048729

Tissue morphogenesis

4.00E−05

BCL2

GO:0030217

T cell differentiation

8.10E−05

BCL2, STAT5B, SOX4

GO:0002009

Morphogenesis of an epithelium

1.50E−04

BCL2

GO:0030098

Lymphocyte differentiation

8.90E−04

BCL2, STAT5B, SOX4