Putative markers for the detection of early-stage bladder cancer selected by urine metabolomics

BMC Bioinformatics

Table 1 Selected putative markers

Compound name	Mass	Metabolite	Accuracy	Sensitivity	Specificity
Benzenepropanoic acid, 4-dihydroxy-, methyl ester(CAS)	107	Desaminotyrosine	0.68	0.61	0.76
3,8,Dioxa2,9,disiladecane,2,2,9,9,tetramethyl,5,6,bis-trimethylsilyl-oxy,R,S,CAS,3	217	Erythritol	0.94	0.92	0.96
Pentitol-1,1-D2,2-desoxy-tetrakis-O(trimethylsilyl)	231	unknown	0.81	0.75	0.88
d-Ribose,2,3,4,5,tetrakis-O-trimethylsilyl-o-methyloxime,CAS	103	d-Ribose	0.74	0.55	0.94
Ribitol,1,2,3,4,5,pentatms,7	217	Ribitol	0.84	0.75	0.94
d,Fructose,1,3,4,5,6,pentakis-O-trimethylsilyl-O-methyloxime-CAS,3	217	d-Fructose	0.84	0.75	0.94
d-Mannose,2,3,4,5,6,pentakis-O-trimethylsilyl-o-methyloxyme-1Z,3	160	d-Mannose	0.86	0.80	0.92
d-Galactose,2,3,4,5,6,pentakis-O-trimethylsilyl-o-methyloxyme,1Z,5	103	d-Galactose	0.80	0.65	0.96

Performance was reported by LOOCV on the marker discovery cohort. The third compound cannot be identified as any metabolite and accordingly annotated as ‘unknown’

ISSN: 1471-2105