From: Performance of Web tools for predicting changes in protein stability caused by mutations
PoPMuSiC | DynaMut | DUET | INPS-MD | MAESTROweb | |
---|---|---|---|---|---|
Values calculated for mutations causing a ΔΔG >|0.5|kcal/mol | |||||
True negative | 94 | 52 | 89 | 95 | 86 |
False positive | 8 | 50 | 13 | 7 | 16 |
True positive | 44 | 80 | 64 | 49 | 62 |
False negative | 58 | 22 | 38 | 53 | 40 |
Accuracy | 0.68 | 0.65 | 0.75 | 0.71 | 0.73 |
True negative rate (specificity) | 0.92 | 0.51 | 0.87 | 0.93 | 0.84 |
True positive rate (sensitivity) | 0.43 | 0.78 | 0.63 | 0.48 | 0.61 |
Positive predictive value (precision) | 0.85 | 0.62 | 0.83 | 0.88 | 0.79 |
Negative predictive value | 0.62 | 0.70 | 0.70 | 0.64 | 0.68 |
MCC | 0.40 | 0.31 | 0.52 | 0.46 | 0.46 |
Values calculated for mutations causing a ΔΔG ≤|0.5|kcal/mol | |||||
True negative | 65 | 35 | 57 | 64 | 47 |
False positive | 15 | 45 | 23 | 16 | 33 |
True positive | 27 | 50 | 33 | 25 | 43 |
False negative | 52 | 29 | 46 | 54 | 36 |
Accuracy | 0.58 | 0.53 | 0.57 | 0.56 | 0.57 |
True negative rate (specificity) | 0.81 | 0.44 | 0.71 | 0.80 | 0.59 |
True positive rate (sensitivity) | 0.34 | 0.63 | 0.42 | 0.32 | 0.54 |
Positive predictive value (precision) | 0.64 | 0.53 | 0.59 | 0.61 | 0.57 |
Negative predictive value | 0.56 | 0.55 | 0.55 | 0.54 | 0.57 |
MCC | 0.17 | 0.07 | 0.14 | 0.13 | 0.13 |