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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Pre-capture multiplexing provides additional power to detect copy number variation in exome sequencing

Fig. 2

Mean-variance relationship demonstrates less dispersion in multiplexed capture. a Agilent (AGL) capture pools; b integrated DNA Technologies (IDT) capture pools. Mean counts per exon given on the horizontal axis; mean variance per exon given on the vertical axis. Contours show the distribution of points by pool. Dotted lines show the ordinary least squares regression fit. Orange indicates multiplexed capture pools; blue indicates independently captured pools. The dashed gray line represents the 1:1 relationship expected under a Poisson process. Lines above the plot show the density of mean values by pool; lines to the right of the plot show the density of variance values by pool

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BMC Bioinformatics

ISSN: 1471-2105

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