Table 5 The top 10 genes selected via TGLRR on PAAD-ESCA-HNSC
Gene ED | Relevance score | Related diseases | Coded proteins |
|---|---|---|---|
CDH1 | 101.03, 96.95, 124.3, 107.43 | Gastric, breast, colorectal, thyroid and ovarian cancer | Cadherin superfamily |
TGFB1 | 73.21, 44.14, 76.66, 64.67 | Camurati-Engelmann disease, Encephalopathy, Inflammatory Bowel Disease and Immunodeficiency | Transforming Growth Factor-Beta Superfamily of Proteins |
RELA | 27.63, 11.33, 41.36, 26.77 | Mucocutaneous Ulceration, Chronic and Ependymoma | Transcription Factor |
ANXA5 | 26.80, 10.31, 42.30, 26.47 | Pregnancy Loss, Recurrent 3 and Antiphospholipid Syndrome | Calcium-Dependent Phospholipid Binding Proteins |
RHOA | 27.48, 11.81, 31.46, 23.58 | Adenocarcinoma and Peripheral T-Cell Lymphoma | Rho Family of Small GTPases |
PTPN11 | 13.04, 13.56, 43.23, 23.28 | Noonan Syndrome 1 and Juvenile Myelomonocytic Leukemia | Protein Tyrosine Phosphatase |
CTNNA1 | 20.94, 19.40, 24.80, 21.71 | Macular Dystrophy, Patterned, 2 and Butterfly-Shaped Pigment Dystrophy | Cell Adhesion Process Protein |
IGF2R | 13.40, 19.07, 25.26, 19.24 | Hepatocellular Carcinoma and Inclusion-Cell Disease | Receptor for Both Insulin-Like Growth Factor 2 and Mannose 6-Phosphate |
RUNX1 | 10.85, 12.97, 25.61, 16.48 | Platelet Disorder, Familial, with Associated Myeloid Malignancy, leukemia and Isolated Delta-Storage Pool Disease | Transcription Factor |
EWSR1 | 12.55, 9.19, 27.33, 16.36 | Ewing Sarcoma and Desmoplastic Small Round Cell Tumor | Multifunctional Protein |