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Table 1 Definitions of the centrality parameters considered in this analysis

From: Centrality of drug targets in protein networks

Size dependent parameters
Average shortest path: average distance between an examined node and all other nodes
Degree: number of edges connected to an examined node
Eccentricity: largest number of edges between an examined node and any node in the network
Neighborhood connectivity: average number of edges of nodes neighboring an examined node
Stress: number of shortest paths between any two nodes passing through an examined node
Normalized parameters
Betweenness centrality: fraction of shortest paths between any two nodes passing through an examined node
Closeness centrality: normalized reciprocal distance between an examined node and any node
Clustering coefficient (local): observed fraction of all possible edges between nodes neighboring an examined node
Topological coefficient: fraction of nodes neighboring an examined node that are shared with other nodes