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Table 2 Temporal evolution of protein states in Sic1 gene deletion

From: Boolean factor graph model for biological systems: the yeast cell-cycle network

Time Genes Phase
Cln3 MBF SBF Cln1,2 Cdh1 Swi5 Cdc20,14 Clb5,6 Sic1 Clb1,2 Mcm1,SFF
1 1 0 0 0 1 0 0 0 0 0 0 Start
2 0 1 1 0 1 0 0 0 0 0 0 G\(_{1}\)
3 0 1 1 1 1 0 0 1 0 0 0 S
4 0 1 1 1 0 0 0 1 0 0 1 G\(_{2}\)
5 0 1 1 1 0 1 1 1 0 1 1 G\(_{2}\)
6 0 0 0 1 0 1 1 1 0 1 1 M
7 0 0 0 0 0 1 1 0 0 1 1 M
  1. The cell cycle gets stuck in the M phase. The “Start” phase refers to a series of linked events that prepare a cell for budding and DNA replication. Completion of the “Start” phase and commitment to a new cycle of cell division precedes the actual end of the G\(_{1}\) phase. Bold states in the sequence rows denote the state of the deleted node. Also, the number of time steps in each phase does not reflect its actual duration