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Table 2 Temporal evolution of protein states in Sic1 gene deletion

From: Boolean factor graph model for biological systems: the yeast cell-cycle network

Time

Genes

Phase

Cln3

MBF

SBF

Cln1,2

Cdh1

Swi5

Cdc20,14

Clb5,6

Sic1

Clb1,2

Mcm1,SFF

1

1

0

0

0

1

0

0

0

0

0

0

Start

2

0

1

1

0

1

0

0

0

0

0

0

G\(_{1}\)

3

0

1

1

1

1

0

0

1

0

0

0

S

4

0

1

1

1

0

0

0

1

0

0

1

G\(_{2}\)

5

0

1

1

1

0

1

1

1

0

1

1

G\(_{2}\)

6

0

0

0

1

0

1

1

1

0

1

1

M

7

0

0

0

0

0

1

1

0

0

1

1

M

  1. The cell cycle gets stuck in the M phase. The “Start” phase refers to a series of linked events that prepare a cell for budding and DNA replication. Completion of the “Start” phase and commitment to a new cycle of cell division precedes the actual end of the G\(_{1}\) phase. Bold states in the sequence rows denote the state of the deleted node. Also, the number of time steps in each phase does not reflect its actual duration