Table 3 AUCs for TWLNI, where \(\tau\) used in Algorithm 1 are respectively set to 1, 3 and 5
From: Drug–target interaction prediction via multiple classification strategies
Dataset | \(\tau\) | 1 | 3 | 5 | Mean |
|---|---|---|---|---|---|
NR | DT | 51.90 ± 0.19 | 47.30 ± 0.23 | 47.30 ± 0.23 | 48.83 |
RF | 76.10 ± 0.40 | 77.30 ± 0.30 | 67.80 ± 0.36 | 73.73 | |
NP | 69.50 ± 2.00 | 74.90 ± 0.37 | 73.90 ± 0.70 | 72.77 | |
WP | 72.80 ± 0.22 | 80.60 ± 0.80 | 75.40 ± 0.10 | 76.27 | |
NBI | 72.40 ± 0.30 | 79.70 ± 0.80 | 73.80 ± 0.20 | 75.30 | |
RLS | 77.00 ± 0.32 | 87.10 ± 0.40 | 88.20 ± 0.49 | 84.10 | |
RK | 78.60 ± 0.30 | 87.80 ± 0.37 | 88.50 ± 0.40 | 84.97 | |
EDT | 81.70 ± 0.42 | 86.10 ± 0.10 | 81.20 ± 0.35 | 83.00 | |
EKRR | 76.40 ± 0.35 | 87.40 ± 0.29 | 88.70 ± 0.39 | 84.17 | |
ours | 84.17 ± 0.48 | 90.12 ± 0.46 | 90.54 ± 0.56 | 88.28 | |
IC | DT | 51.30 ± 0.18 | 53.30 ± 0.33 | 54.30 ± 0.34 | 52.97 |
RF | 67.70 ± 0.27 | 72.10 ± 0.12 | 72.90 ± 0.11 | 70.90 | |
NP | 62.60 ± 0.10 | 64.30 ± 0.40 | 66.10 ± 0.60 | 64.33 | |
WP | 72.50 ± 0.54 | 76.60 ± 0.50 | 77.40 ± 0.13 | 75.50 | |
NBI | 72.30 ± 0.54 | 76.40 ± 0.40 | 77.20 ± 0.13 | 75.30 | |
RLS | 68.30 ± 0.67 | 70.60 ± 0.45 | 71.40 ± 0.42 | 70.10 | |
RK | 68.40 ± 0.57 | 70.50 ± 0.36 | 71.00 ± 0.31 | 69.97 | |
EDT | 71.50 ± 0.24 | 76.00 ± 0.18 | 77.20 ± 0.35 | 74.90 | |
EKRR | 69.50 ± 0.64 | 71.60 ± 0.38 | 72.50 ± 0.33 | 71.20 | |
ours | 72.50 ± 0.43 | 78.08 ± 0.54 | 79.71 ± 0.54 | 76.77 | |
GPCR | DT | 59.90 ± 0.20 | 62.60 ± 0.80 | 62.70 ± 0.13 | 61.73 |
RF | 78.00 ± 0.18 | 77.60 ± 1.90 | 77.80 ± 0.19 | 77.80 | |
NP | 67.80 ± 0.10 | 69.30 ± 0.40 | 70.30 ± 0.20 | 69.13 | |
WP | 81.90 ± 0.11 | 80.40 ± 0.22 | 80.70 ± 0.20 | 81.00 | |
NBI | 81.80 ± 0.11 | 80.40 ± 0.22 | 80.60 ± 0.19 | 80.93 | |
RLS | 81.50 ± 0.11 | 81.20 ± 0.14 | 81.00 ± 0.15 | 81.23 | |
RK | 82.00 ± 0.40 | 81.00 ± 0.11 | 80.90 ± 0.13 | 82.30 | |
EDT | 82.70 ± 0.12 | 82.20 ± 0.21 | 83.00 ± 0.15 | 82.63 | |
EKRR | 82.50 ± 0.09 | 82.30 ± 0.12 | 82.30 ± 0.14 | 82.37 | |
Ours | 84.19 ± 0.96 | 84.71 ± 0.38 | 85.05 ± 0.56 | 84.65 | |
E | DT | 61.60 ± 0.25 | 63.00 ± 0.45 | 63.40 ± 0.56 | 62.67 |
RF | 76.90 ± 0.80 | 80.70 ± 0.10 | 81.10 ± 0.06 | 79.57 | |
NP | 74.80 ± 0.30 | 71.90 ± 0.80 | 72.00 ± 0.80 | 72.90 | |
WP | 85.00 ± 0.30 | 85.30 ± 0.70 | 85.50 ± 0.12 | 85.27 | |
NBI | 84.90 ± 0.30 | 85.20 ± 0.70 | 85.40 ± 0.12 | 85.17 | |
RLS | 76.70 ± 0.40 | 74.30 ± 0.10 | 74.40 ± 0.21 | 75.13 | |
RK | 77.40 ± 0.13 | 75.90 ± 0.40 | 76.20 ± 0.17 | 76.50 | |
EDT | 82.20 ± 0.20 | 84.50 ± 0.30 | 84.70 ± 0.80 | 83.80 | |
EKRR | 77.30 ± 0.50 | 75.30 ± 0.24 | 75.80 ± 0.38 | 76.13 | |
Ours | 85.83 ± 0.47 | 87.95 ± 0.36 | 88.10 ± 0.53 | 87.29 | |
DB | DT | 65.70 ± 0.48 | 69.30 ± 0.64 | 70.30 ± 0.58 | 68.43 |
RF | 82.50 ± 0.60 | 85.30 ± 0.56 | 86.50 ± 0.76 | 84.77 | |
NP | 69.70 ± 0.78 | 72.50 ± 0.46 | 72.90 ± 0.80 | 71.70 | |
WP | 84.20 ± 0.64 | 78.20 ± 0.62 | 73.30 ± 0.48 | 78.57 | |
NBI | 64.40 ± 0.93 | 58.90 ± 0.79 | 55.90 ± 0.53 | 59.73 | |
RLS | 88.10 ± 0.75 | 87.70 ± 0.39 | 87.30 ± 0.35 | 87.70 | |
RK | 88.30 ± 0.66 | 89.00 ± 0.60 | 88.70 ± 0.65 | 88.67 | |
EDT | 87.50 ± 0.58 | 88.32 ± 0.62 | 88.89 ± 0.49 | 88.24 | |
EKRR | 91.00 ± 0.68 | 92.10 ± 0.86 | 92.40 ± 0.57 | 91.83 | |
Ours | 92.38 ± 0.58 | 92.97 ± 0.72 | 93.25 ± 0.66 | 92.87 |