Drug–target interaction prediction via multiple classification strategies

Ye, Qing; Zhang, Xiaolong; Lin, Xiaoli

doi:10.1186/s12859-021-04366-3

BMC Bioinformatics

Table 4 AUCs for TWSNI, where \(\tau\) used in Algorithm 1 are respectively set to 1, 3 and 5

From: Drug–target interaction prediction via multiple classification strategies

Dataset	\(\tau\)	1	3	5	Mean
NR	DT	49.90 ± 0.54	54.30 ± 0.32	53.20 ± 0.31	52.47
	RF	51.10 ± 0.61	63.90 ± 0.51	66.40 ± 0.44	60.47
	WP	32.30 ± 0.64	53.90 ± 0.58	58.30 ± 0.44	48.17
	NBI	40.20 ± 0.54	54.80 ± 0.60	58.60 ± 0.44	51.20
	RLS	52.90 ± 0.65	66.20 ± 0.49	69.90 ± 0.48	63.00
	RK	49.10 ± 0.63	66.00 ± 0.51	69.40 ± 0.48	61.50
	EDT	44.70 ± 0.73	63.00 ± 0.70	66.70 ± 0.51	58.13
	EKRR	51.00 ± 0.59	66.20 ± 0.52	69.60 ± 0.45	62.67
	ours	53.90 ± 0.47	65.30 ± 0.52	67.90 ± 0.33	62.37
IC	DT	46.70 ± 0.70	48.70 ± 0.41	50.30 ± 0.43	48.57
	RF	41.90 ± 0.48	54.60 ± 0.34	61.50 ± 0.33	52.67
	WP	37.40 ± 0.59	50.80 ± 0.55	60.70 ± 0.45	49.63
	NBI	32.40 ± 0.69	50.40 ± 0.57	60.20 ± 0.44	47.67
	RLS	51.30 ± 0.73	58.80 ± 0.41	63.00 ± 0.32	57.70
	RK	46.40 ± 0.91	60.50 ± 0.40	65.30 ± 0.32	57.40
	EDT	34.10 ± 0.58	54.60 ± 0.49	62.90 ± 0.39	50.53
	EKRR	50.90 ± 0.76	60.10 ± 0.53	65.50 ± 0.42	58.83
	ours	54.50 ± 0.51	54.40 ± 0.34	57.20 ± 0.36	55.37
GPCR	DT	50.50 ± 0.58	53.10 ± 0.37	57.30 ± 0.28	53.63
	RF	56.80 ± 0.68	69.40 ± 0.32	73.50 ± 0.26	66.57
	WP	40.80 ± 0.68	58.40 ± 0.30	64.10 ± 0.21	54.43
	NBI	40.80 ± 0.65	58.00 ± 0.29	64.10 ± 0.20	54.30
	RLS	71.90 ± 0.53	80.40 ± 0.30	81.50 ± 0.23	77.93
	RK	71.80 ± 0.56	79.20 ± 0.32	80.40 ± 0.25	77.13
	EDT	55.80 ± 0.52	70.00 ± 0.30	74.80 ± 0.23	66.87
	EKRR	72.50 ± 0.48	80.80 ± 0.26	82.00 ± 0.20	78.43
	ours	51.70 ± 0.28	59.60 ± 0.21	63.00 ± 0.13	58.10
E	DT	58.90 ± 0.18	61.40 ± 0.14	61.00 ± 0.21	60.43
	RF	58.90 ± 0.27	64.10 ± 0.17	67.90 ± 0.18	63.63
	WP	44.20 ± 0.21	47.40 ± 0.22	56.90 ± 0.29	49.50
	NBI	44.70 ± 0.28	47.60 ± 0.16	57.10 ± 0.32	49.80
	RLS	67.50 ± 0.22	68.30 ± 0.22	72.60 ± 0.24	69.47
	RK	67.00 ± 0.27	70.30 ± 0.27	72.90 ± 0.29	70.07
	EDT	58.00 ± 0.28	63.10 ± 0.19	68.30 ± 0.23	63.13
	EKRR	64.20 ± 0.22	65.70 ± 0.22	71.20 ± 0.25	67.03
	ours	70.20 ± 0.19	71.70 ± 0.12	69.70 ± 0.40	70.53
DB	DT	51.20 ± 0.52	57.30 ± 0.37	58.80 ± 0.39	55.77
	RF	54.40 ± 0.65	58.60 ± 0.68	62.20 ± 0.75	58.40
	WP	56.70 ± 0.37	45.10 ± 0.46	53.00 ± 0.38	51.60
	NBI	60.80 ± 0.45	60.20 ± 0.57	59.80 ± 0.57	60.27
	RLS	43.50 ± 0.76	51.60 ± 0.62	65.80 ± 0.63	53.63
	RK	65.40 ± 0.59	70.50 ± 0.65	73.70 ± 0.68	69.87
	EDT	52.39 ± 0.62	55.60 ± 0.49	63.30 ± 0.54	57.10
	EKRR	39.90 ± 0.38	53.30 ± 0.38	60.5. ± 0.38	51.23
	ours	62.50 ± 0.62	63.70 ± 0.67	64.50 ± 0.57	63.57

The maximum and second maximum AUC are shown in bold and italics

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