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Fig. 14 | BMC Bioinformatics

Fig. 14

From: Mathematical modelling of SigE regulatory network reveals new insights into bistability of mycobacterial stress response

Fig. 14

Input–output relationship for Module 2 under the assumption of non-constant RseA concentration. (a) Block diagram. (b) Nullclines of the subsystem obtained from differential Eq. (15) together with ODEs (5)–(14) upon substitution of \(R_T\) with R. The blue thick line represents the amount of total SigE as a function of free SigE (reported on the x-axis). Total SigE concentration has been computed as the summation of free SigE (dashed red line) and complexes in which SigE is bounded by RseA and/or ClpC1P2 (various colours and traits). Inset: magnification of the area within the gray rectangle

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BMC Bioinformatics

ISSN: 1471-2105

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