Fig. 6

Prion/Double Phosphorylation motif with prion-like conformation conversion between the two states of the same protein. One of the conformations is assumed to be an active kinase. a SBGN [30] representation of the reaction network constructed using CellDesigner [31] and b its C-graph representation. E1 and E2 indicate alternative forms of a kinase enzyme. Only E2 is active. S, S* and S** (labeled with p on panel a) is a substrate in unmodified, phosphorylated, and doubly phosphorylated forms. E1E2 and E2E1 are the protein complexes that mediate conversion from one form into another