Skip to main content

Table 2 The HRD Score and BRCA1/2 mutations and methylation of 17 OC and BC cell lines

From: GSA: an independent development algorithm for calling copy number and detecting homologous recombination deficiency (HRD) from target capture sequencing

Cell line Cancer type LOH TAI LST ploidy HRD score BRCA1/2 mutation BRCA1-methylation (%)
HCC38 BRCA 30 24 71 3.34 73.21 WT 74.33
HCC1806 BRCA 34 23 42 2.29 63.47 WT 1.41
NCI/ADR-RES OV 32 19 47 2.32 61.99 WT 64.64
HCC1143 BRCA 28 20 67 3.59 59.35 WT 1.26
HCC70 BRCA 29 23 57 3.22 59.13 WT 0.28
MX-1 BRCA 30 21 50 2.72 58.90 BRCA1 c.2679_2682delGAAA p.K893Nfs*106 frameshift 99.84% 2.40
OVCAR4 OV 29 19 55 3.12 54.67 WT 47.56
HCC1428 BRCA 17 17 53 3.62 30.82 WT 0.31
ZR-75-1 BRCA 9 15 40 3.20 14.42 WT 0.17
MDA-MB-453 BRCA 11 16 48 4.17 10.42 WT 0.45
MDA-MB-231 BRCA 11 11 30 2.78 8.90 WT 0.19
MDA-MB-361 BRCA 6 13 46 3.67 8.18 WT 1.91
MDA-MB-415 BRCA 9 13 34 3.09 8.10 WT 0.09
ZR-75-30 BRCA 7 13 41 3.67 4.10 WT 3.77
HS-578T BRCA 10 7 16 2.47  − 5.33 WT 0.22
IGR-OV1 OV 7 0 7 1.85  − 14.73 BRCA1 c.1961delA p.K654Sfs*47 frameshift 50.07% 0.15
A2780 OV 3 3 4 2.01  − 21.19 WT 0.69