Table 2 Information summary of the constructed features and their influence coefficient

The neighborhood similarity information

Information based on the similarities between the specific disease (target) and its neighborhoods

\(\mathrm{Fea}1\)

The average similarity between the specific disease and its neighborhoods which did not have known associations with the specific target

\(\text{DDS TDA}\)

\(\mathrm{Fea}2\)

The average similarity between the specific target and its neighborhoods which did not have known associations with the specific disease

\(\text{TTS TDA}\)

\(\mathrm{Fea}3\)

The sum of weights for paths which connected by the nearest neighborhood of the specific target and the nearest neighborhood of the specific disease

\(\text{TTS DDS }\)\(\mathrm{TDA}\)

The drug-inferred information

Information inferred by drugs based on the drug-target-disease mechanism

\(\mathrm{Fea}4\)

The maximum quotient of the average weight for the specific disease-drug paths divided by the average weight for the specific target-drug paths

\(\text{TDI DDA }{\mathrm{MMS}}\_{\mathrm{T}}\text{ MMS}\_\mathrm{D}\)

The path information

Information from paths (length = 2 and length = 3) between the specific target and the specific disease

\(\mathrm{Fea}5\)

The average weight of paths from the specific target to the specific disease based on target-target-disease pattern

\(\text{TTS TDA}\)

\(\mathrm{Fea}6\)

The same as above but based on target-disease-disease pattern

\({\text{DDS TDA}}\)

\({\text{Fea}}7\)

The same as above but based on target-target-target-disease pattern

\({\text{TTS TDA}}\)

\({\text{Fea}}8\)

The same as above but based on target-target-disease-disease pattern

\({\text{TTS DDS TDA}}\)

\({\text{Fea}}9\)

The same as above but based on target-disease-disease-disease pattern

\({\text{DDS TDA}}\)