Table 4 Top-five most predictive pathways in the {PathDIP, CAT} model
From: Machine learning-based predictions of dietary restriction associations across ageing-related genes
Feature | Definition | Score | \(Ageing_{DR}\) (%) | \(Ageing_{NotDR}\) (%) | Adjusted p value |
|---|---|---|---|---|---|
KEGG.2 | Autophagy (animal) | 100 | 18.18% {20/110} | 4.34% {38/876} | 3.05e−0.5 |
KEGG.30 | Longevity regulating pathway (multiple.species) | 45.349 | 12.73% {14/110} | 2.63% {23/876} | 8.71e−04 |
NetPath.23 | BDNF | 38.953 | 0.91% {1/110} | 1.14% {10/876} | 1 |
REACTOME.10 | Cellular responses to external stimuli | 37.791 | 20.91% {23/110} | 9.13% {80/876} | 3.90e−01 |
WikiPathways.37 | NRF2 | 34.884 | 14.55% {16/110} | 1.14% {10/876} | 2.58e−12 |