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Table 4 Top-five most predictive pathways in the {PathDIP, CAT} model

From: Machine learning-based predictions of dietary restriction associations across ageing-related genes

Feature Definition Score \(Ageing_{DR}\) (%) \(Ageing_{NotDR}\) (%) Adjusted p value
KEGG.2 Autophagy (animal) 100 18.18%
{20/110}
4.34%
{38/876}
3.05e−0.5
KEGG.30 Longevity regulating pathway (multiple.species) 45.349 12.73%
{14/110}
2.63%
{23/876}
8.71e−04
NetPath.23 BDNF 38.953 0.91%
{1/110}
1.14%
{10/876}
1
REACTOME.10 Cellular responses to external stimuli 37.791 20.91%
{23/110}
9.13%
{80/876}
3.90e−01
WikiPathways.37 NRF2 34.884 14.55%
{16/110}
1.14%
{10/876}
2.58e−12