|
A
|
Antibiotic concentration
|
mg/L
|
e.g., 5 mg/L
|
Measured/external source
|
|
\(B_{0}\)
|
Starting population
|
Number of bacteria
|
\(1e^{6}\)
|
Assumption
|
|
n
|
Target molecules
|
Molecules
|
100
|
Assumption
|
|
\(D_{0}\)
|
Maximum death rate
|
\(\text{s}^{-1}\)
|
\(1.6e^{-5}\)
|
[28]
|
|
\(R_{0}\)
|
Maximum replication rate
|
\(\text{s}^{-1}\)
|
\(9.25833e^{-6}\)
|
[28]
|
|
\(k_{T}\)
|
Killing threshold
| |
99
|
From \(f_{c}\) of Eq (3) [29]
|
| | | | |
\(MIC=\frac{K_{D}f_{c}}{1-f_{c}}\)
|
|
\(r_{T}\)
|
Replication threshold
| |
98
|
From \(f_{c}\) of Eq (3) [29]
|
| | | | |
\(MIC=\frac{K_{D}f_{c}}{1-f_{c}}\)
|
|
\(k_{f}\)
|
Binding rate
|
\(\text{M}^{-1}\text{s}^{-1}\)
|
\(1.2e^{6}\)
|
[30]
|
|
\(k_{r}\)
|
Unbinding rate
|
\(\text{s}^{-1}\)
|
0.001284
|
[30]
|
|
W
|
Drug molecular weight
|
g/mol
|
822.94
|
[31]
|
|
C
|
Carrying capacity
|
Bacteria/ml
|
\(1e^{9}\)
|
[29]
|
|
V
|
Intracellular volume
|
L/bacterial cell
|
\(1e^{-15}\)
|
[29]
|
|
MIC
|
Minimum inhibitory concentration
|
mg/L
|
0.4
|
[28]
|
