Table 1 Model-parameter values when using Rifampicin in TB patients. These values are identified from the literature
Parameter | Description | Unit | Value | References |
|---|---|---|---|---|
A | Antibiotic concentration | mg/L | e.g., 5 mg/L | Measured/external source |
\(B_{0}\) | Starting population | Number of bacteria | \(1e^{6}\) | Assumption |
n | Target molecules | Molecules | 100 | Assumption |
\(D_{0}\) | Maximum death rate | \(\text{s}^{-1}\) | \(1.6e^{-5}\) | [28] |
\(R_{0}\) | Maximum replication rate | \(\text{s}^{-1}\) | \(9.25833e^{-6}\) | [28] |
\(k_{T}\) | Killing threshold | 99 | From \(f_{c}\) of Eq (3) [29] | |
\(MIC=\frac{K_{D}f_{c}}{1-f_{c}}\) | ||||
\(r_{T}\) | Replication threshold | 98 | From \(f_{c}\) of Eq (3) [29] | |
\(MIC=\frac{K_{D}f_{c}}{1-f_{c}}\) | ||||
\(k_{f}\) | Binding rate | \(\text{M}^{-1}\text{s}^{-1}\) | \(1.2e^{6}\) | [30] |
\(k_{r}\) | Unbinding rate | \(\text{s}^{-1}\) | 0.001284 | [30] |
W | Drug molecular weight | g/mol | 822.94 | [31] |
C | Carrying capacity | Bacteria/ml | \(1e^{9}\) | [29] |
V | Intracellular volume | L/bacterial cell | \(1e^{-15}\) | [29] |
MIC | Minimum inhibitory concentration | mg/L | 0.4 | [28] |