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Fig. 1 | BMC Bioinformatics

Fig. 1

From: GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism

Fig. 1

The challenge of CYP11B1/CYP11B2 chimeric form identification. A Scheme of the CYP11B1/CYP11B2 chimeric gene. B Long-range PCR shows the PCR products of the CYP11B1/CYP11B2 chimeric gene and unexpected fragments. Amplification of a chimeric gene is expected to produce a 3.9 kb product. Case A has a clear single band of the expected size of the PCR product, but cases B and C have multiple bands with weak signals of the expected size of the main product. C Dot plot revealing the high degree of similarity between the CYP11B1 and CYP11B2 genomic sequences. The plot was generated by blast2seq using default parameters

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BMC Bioinformatics

ISSN: 1471-2105

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