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Table 1 Mann-Whitney U statistic and p-values calculated from Mann-Whitney U test to determine a significant difference in average AUROCs and PRCs of signature similarity matrix rankings of the unweighted drug set created from AutoRIF and randomly shuffled predictions across libraries of drug-related terms that were queried using DrugShot

From: DrugShot: querying biomedical search terms to retrieve prioritized lists of small molecules

Library

AUROC evaluation

PRC evaluation

U-statistic

p-value

U-statistic

p-value

SIDER side effects (1298 terms)

1,495,996

9.12E−257

922,468

2.75E−05

SIDER indications (835 terms)

626,342

8.62E−175

402,517

4.48E−08

Drug repurposing hub MoA (154 terms)

20,213

2.82E−36

14,484

1.62E−06

GO biological processes (1364 terms)

898,342

6.53E−295

776,522

7.79E−156