| A class—receptors | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F1 | Accuracy | Precision | Recall | MCC | AUC-ROC | |||||||
HSS-PPI | ||||||||||||
Residue Sequence | 0.328 | 0.345 | 0.851 | 0.857 | 0.243 | 0.265 | 0.534 | 0.548 | 0.287 | 0.306 | 0.845 | 0.835 |
Contact Map 6 Ă… | 0.622 | 0.629 | 0.947 | 0.930 | 0.631 | 0.526 | 0.665 | 0.864 | 0.608 | 0.631 | 0.975 | 0.980 |
Contact Map 8 Ă… | 0.630 | 0.620 | 0.950 | 0.925 | 0.658 | 0.502 | 0.660 | 0.889 | 0.620 | 0.624 | 0.974 | 0.978 |
Contact Map 10 Ă… | 0.578 | 0.628 | 0.920 | 0.940 | 0.467 | 0.602 | 0.823 | 0.724 | 0.576 | 0.617 | 0.970 | 0.975 |
Contact Map 12 Ă… | 0.552 | 0.580 | 0.932 | 0.920 | 0.523 | 0.483 | 0.645 | 0.801 | 0.535 | 0.574 | 0.966 | 0.967 |
Hierarchical Representation 6Ă… | 0.657 | 0.592 | 0.952 | 0.910 | 0.667 | 0.447 | 0.701 | 0.951 | 0.647 | 0.609 | 0.971 | 0.978 |
Hierarchical Representation 8Ă… | 0.647 | 0.665 | 0.950 | 0.945 | 0.663 | 0.608 | 0.690 | 0.803 | 0.637 | 0.659 | 0.976 | 0.980 |
Hierarchical Representation 10Ă… | 0.619 | 0.632 | 0.952 | 0.927 | 0.718 | 0.510 | 0.595 | 0.907 | 0.615 | 0.638 | 0.975 | 0.978 |
Hierarchical Representation 12Ă… | 0.619 | 0.604 | 0.948 | 0.918 | 0.656 | 0.474 | 0.647 | 0.910 | 0.611 | 0.612 | 0.975 | 0.977 |
Other methods | ||||||||||||
Daberdaku et. al. | 0.272 | 0.274 | 0.862 | 0.876 | 0.166 | 0.169 | 0.917 | 0.883 | 0.346 | 0.341 | 0.954 | 0.939 |
SPPIDER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.773 | 0.754 |
NPS-HomPPI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.796 | 0.780 |
PrISE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.770 | 0.758 |
 | AB class—receptors | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F1 | Accuracy | Precision | Recall | MCC | AUC-ROC | |||||||
HSS-PPI | ||||||||||||
Residue Sequence | 0.212 | 0.244 | 0.886 | 0.750 | 0.265 | 0.167 | 0.214 | 0.537 | 0.168 | 0.188 | 0.727 | 0.737 |
Contact Map 6 Ă… | 0.432 | 0.400 | 0.930 | 0.930 | 0.535 | 0.391 | 0.425 | 0.443 | 0.422 | 0.382 | 0.942 | 0.939 |
Contact Map 8 Ă… | 0.300 | 0.316 | 0.929 | 0.931 | 0.496 | 0.466 | 0.276 | 0.297 | 0.323 | 0.327 | 0.945 | 0.955 |
Contact Map 10 Ă… | 0.406 | 0.293 | 0.924 | 0.926 | 0.589 | 0.304 | 0.391 | 0.302 | 0.424 | 0.291 | 0.958 | 0.965 |
Contact Map 12 Ă… | 0.357 | 0.359 | 0.909 | 0.914 | 0.488 | 0.317 | 0.455 | 0.454 | 0.370 | 0.353 | 0.956 | 0.964 |
Hierarchical Representation 6Ă… | 0.428 | 0.347 | 0.921 | 0.913 | 0.501 | 0.383 | 0.446 | 0.423 | 0.411 | 0.332 | 0.886 | 0.886 |
Hierarchical Representation 8Ă… | 0.450 | 0.407 | 0.921 | 0.925 | 0.491 | 0.566 | 0.492 | 0.484 | 0.431 | 0.417 | 0.918 | 0.928 |
Hierarchical Representation 10Ă… | 0.412 | 0.415 | 0.930 | 0.931 | 0.601 | 0.615 | 0.424 | 0.473 | 0.417 | 0.429 | 0.948 | 0.953 |
Hierarchical Representation 12Ă… | 0.281 | 0.340 | 0.923 | 0.929 | 0.439 | 0.469 | 0.264 | 0.341 | 0.292 | 0.348 | 0.955 | 0.963 |
Other methods | ||||||||||||
Daberdaku et. al. | 0.230 | 0.228 | 0.910 | 0.913 | 0.161 | 0.156 | 0.590 | 0.546 | 0.256 | 0.250 | 0.890 | 0.845 |
SPPIDER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.757 | 0.783 |
NPS-HomPPI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.701 | 0.698 |
PrISE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.776 | 0.789 |
 | EI class—receptors | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F1 | Accuracy | Precision | Recall | MCC | AUC-ROC | |||||||
HSS-PPI | ||||||||||||
Residue Sequence | 0.281 | 0.292 | 0.590 | 0.646 | 0.190 | 0.224 | 0.596 | 0.505 | 0.125 | 0.133 | 0.631 | 0.622 |
Contact Map 6 Ă… | 0.303 | 0.349 | 0.827 | 0.713 | 0.344 | 0.275 | 0.326 | 0.610 | 0.231 | 0.262 | 0.753 | 0.732 |
Contact Map 8 Ă… | 0.364 | 0.363 | 0.725 | 0.722 | 0.283 | 0.280 | 0.604 | 0.594 | 0.270 | 0.271 | 0.753 | 0.729 |
Contact Map 10 Ă… | 0.327 | 0.378 | 0.734 | 0.720 | 0.299 | 0.310 | 0.521 | 0.580 | 0.233 | 0.281 | 0.755 | 0.708 |
Contact Map 12 Ă… | 0.270 | 0.330 | 0.733 | 0.605 | 0.235 | 0.232 | 0.440 | 0.643 | 0.167 | 0.189 | 0.732 | 0.678 |
Hierarchical Representation 6Ă… | 0.329 | 0.342 | 0.817 | 0.744 | 0.320 | 0.289 | 0.369 | 0.507 | 0.237 | 0.236 | 0.749 | 0.725 |
Hierarchical Representation 8Ă… | 0.354 | 0.364 | 0.797 | 0.776 | 0.331 | 0.331 | 0.446 | 0.511 | 0.267 | 0.285 | 0.766 | 0.732 |
Hierarchical Representation 10Ă… | 0.363 | 0.380 | 0.806 | 0.753 | 0.388 | 0.338 | 0.445 | 0.574 | 0.290 | 0.304 | 0.770 | 0.745 |
Hierarchical Representation 12Ă… | 0.414 | 0.362 | 0.760 | 0.668 | 0.348 | 0.275 | 0.611 | 0.681 | 0.324 | 0.278 | 0.783 | 0.732 |
Other methods | ||||||||||||
Daberdaku et. al. | 0.156 | 0.148 | 0.604 | 0.645 | 0.089 | 0.087 | 0.770 | 0.705 | 0.158 | 0.146 | 0.764 | 0.747 |
SPPIDER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.696 | 0.673 |
NPS-HomPPI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.720 | 0.682 |
PrISE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.755 | 0.700 |
 | ER class—receptors | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F1 | Accuracy | Precision | Recall | MCC | AUC-ROC | |||||||
HSS-PPI | ||||||||||||
Residue Sequence | 0.207 | 0.187 | 0.588 | 0.193 | 0.133 | 0.107 | 0.550 | 0.966 | 0.076 | 0.049 | 0.608 | 0.572 |
Contact Map 6 Ă… | 0.186 | 0.211 | 0.106 | 0.691 | 0.106 | 0.157 | 1.000 | 0.480 | 0.000 | 0.115 | 0.635 | 0.663 |
Contact Map 8 Ă… | 0.186 | 0.158 | 0.106 | 0.808 | 0.106 | 0.173 | 1.000 | 0.239 | 0.000 | 0.090 | 0.638 | 0.648 |
Contact Map 10 Ă… | 0.186 | 0.179 | 0.106 | 0.103 | 0.106 | 0.102 | 1.000 | 1.000 | 0.000 | 0.000 | 0.655 | 0.634 |
Contact Map 12 Ă… | 0.186 | 0.179 | 0.106 | 0.101 | 0.106 | 0.101 | 1.000 | 1.000 | 0.000 | 0.000 | 0.693 | 0.614 |
Hierarchical Representation 6Ă… | 0.202 | 0.184 | 0.326 | 0.151 | 0.117 | 0.105 | 0.854 | 0.988 | 0.048 | 0.041 | 0.626 | 0.654 |
Hierarchical Representation 8Ă… | 0.186 | 0.194 | 0.106 | 0.329 | 0.106 | 0.114 | 1.000 | 0.841 | 0.000 | 0.059 | 0.615 | 0.671 |
Hierarchical Representation 10Ă… | 0.186 | 0.195 | 0.106 | 0.245 | 0.106 | 0.112 | 1.000 | 0.929 | 0.000 | 0.039 | 0.590 | 0.654 |
Hierarchical Representation 12Ă… | 0.186 | 0.173 | 0.106 | 0.675 | 0.106 | 0.151 | 1.000 | 0.408 | 0.000 | 0.054 | 0.596 | 0.655 |
Other methods | ||||||||||||
Daberdaku et. al. | 0.145 | 0.109 | 0.733 | 0.747 | 0.089 | 0.065 | 0.580 | 0.465 | 0.136 | 0.092 | 0.734 | 0.663 |
SPPIDER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.731 | 0.736 |
NPS-HomPPI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.588 | 0.589 |
PrISE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.742 | 0.674 |
 | ES class—receptors | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F1 | Accuracy | Precision | Recall | MCC | AUC-ROC | |||||||
HSS-PPI | ||||||||||||
Residue Sequence | 0.257 | 0.232 | 0.512 | 0.278 | 0.163 | 0.137 | 0.663 | 0.879 | 0.097 | 0.070 | 0.596 | 0.565 |
Contact Map 6 Ă… | 0.228 | 0.247 | 0.693 | 0.617 | 0.180 | 0.167 | 0.351 | 0.542 | 0.070 | 0.111 | 0.608 | 0.608 |
Contact Map 8 Ă… | 0.241 | 0.302 | 0.586 | 0.623 | 0.176 | 0.210 | 0.534 | 0.627 | 0.097 | 0.186 | 0.612 | 0.645 |
Contact Map 10 Ă… | 0.255 | 0.292 | 0.621 | 0.601 | 0.215 | 0.201 | 0.524 | 0.672 | 0.131 | 0.192 | 0.621 | 0.660 |
Contact Map 12 Ă… | 0.263 | 0.239 | 0.642 | 0.326 | 0.211 | 0.143 | 0.511 | 0.829 | 0.140 | 0.064 | 0.626 | 0.658 |
Hierarchical Representation 6Ă… | 0.204 | 0.248 | 0.748 | 0.478 | 0.187 | 0.155 | 0.248 | 0.689 | 0.064 | 0.102 | 0.607 | 0.580 |
Hierarchical Representation 8Ă… | 0.236 | 0.261 | 0.678 | 0.663 | 0.185 | 0.184 | 0.388 | 0.511 | 0.080 | 0.135 | 0.621 | 0.604 |
Hierarchical Representation 10Ă… | 0.245 | 0.284 | 0.673 | 0.545 | 0.192 | 0.181 | 0.416 | 0.752 | 0.094 | 0.185 | 0.620 | 0.631 |
Hierarchical Representation 12Ă… | 0.230 | 0.272 | 0.717 | 0.436 | 0.229 | 0.167 | 0.353 | 0.825 | 0.114 | 0.154 | 0.625 | 0.651 |
Other methods | ||||||||||||
Daberdaku et. al. | 0.031 | 0.121 | 0.954 | 0.861 | 0.086 | 0.090 | 0.023 | 0.281 | 0.023 | 0.096 | 0.712 | 0.709 |
SPPIDER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.742 | 0.727 |
NPS-HomPPI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.604 | 0.654 |
PrISE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.742 | 0.664 |
 | OG class—receptors | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F1 | Accuracy | Precision | Recall | MCC | AUC-ROC | |||||||
HSS-PPI | ||||||||||||
Residue Sequence | 0.276 | 0.248 | 0.721 | 0.603 | 0.222 | 0.178 | 0.384 | 0.491 | 0.122 | 0.072 | 0.596 | 0.572 |
Contact Map 6 Ă… | 0.389 | 0.288 | 0.755 | 0.806 | 0.298 | 0.295 | 0.617 | 0.313 | 0.285 | 0.196 | 0.756 | 0.711 |
Contact Map 8 Ă… | 0.305 | 0.274 | 0.580 | 0.532 | 0.210 | 0.176 | 0.705 | 0.735 | 0.163 | 0.157 | 0.728 | 0.730 |
Contact Map 10 Ă… | 0.300 | 0.259 | 0.685 | 0.603 | 0.252 | 0.199 | 0.444 | 0.580 | 0.128 | 0.129 | 0.682 | 0.735 |
Contact Map 12 Ă… | 0.266 | 0.190 | 0.431 | 0.602 | 0.168 | 0.126 | 0.735 | 0.515 | 0.059 | 0.083 | 0.688 | 0.704 |
Hierarchical Representation 6Ă… | 0.359 | 0.244 | 0.744 | 0.772 | 0.281 | 0.230 | 0.550 | 0.324 | 0.240 | 0.140 | 0.717 | 0.662 |
Hierarchical Representation 8Ă… | 0.355 | 0.292 | 0.706 | 0.794 | 0.253 | 0.274 | 0.647 | 0.386 | 0.241 | 0.209 | 0.743 | 0.707 |
Hierarchical Representation 10Ă… | 0.351 | 0.351 | 0.709 | 0.752 | 0.257 | 0.266 | 0.602 | 0.605 | 0.221 | 0.278 | 0.764 | 0.748 |
Hierarchical Representation 12Ă… | 0.323 | 0.326 | 0.692 | 0.778 | 0.239 | 0.285 | 0.555 | 0.496 | 0.175 | 0.259 | 0.744 | 0.742 |
Other methods | ||||||||||||
Daberdaku et. al. | 0.184 | 0.144 | 0.704 | 0.805 | 0.113 | 0.103 | 0.552 | 0.340 | 0.145 | 0.100 | 0.700 | 0.631 |
SPPIDER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.748 | 0.753 |
NPS-HomPPI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.699 | 0.768 |
PrISE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.686 | 0.673 |
 | OR class—receptors | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F1 | Accuracy | Precision | Recall | MCC | AUC-ROC | |||||||
HSS-PPI | ||||||||||||
Residue Sequence | 0.249 | 0.255 | 0.229 | 0.467 | 0.149 | 0.187 | 0.949 | 0.672 | 0.040 | 0.033 | 0.572 | 0.547 |
Contact Map 6 Ă… | 0.191 | 0.201 | 0.582 | 0.540 | 0.138 | 0.179 | 0.407 | 0.424 | -0.002 | -0.009 | 0.577 | 0.507 |
Contact Map 8 Ă… | 0.173 | 0.284 | 0.683 | 0.318 | 0.173 | 0.193 | 0.272 | 0.887 | 0.021 | 0.021 | 0.586 | 0.494 |
Contact Map 10 Ă… | 0.207 | 0.287 | 0.604 | 0.315 | 0.162 | 0.195 | 0.440 | 0.891 | 0.042 | 0.017 | 0.600 | 0.502 |
Contact Map 12 Ă… | 0.245 | 0.288 | 0.531 | 0.316 | 0.167 | 0.196 | 0.587 | 0.897 | 0.067 | 0.027 | 0.621 | 0.492 |
Hierarchical Representation 6Ă… | 0.159 | 0.178 | 0.676 | 0.601 | 0.127 | 0.162 | 0.266 | 0.343 | -0.009 | -0.012 | 0.546 | 0.508 |
Hierarchical Representation 8Ă… | 0.192 | 0.198 | 0.614 | 0.508 | 0.141 | 0.155 | 0.382 | 0.432 | 0.002 | -0.077 | 0.566 | 0.499 |
Hierarchical Representation 10Ă… | 0.172 | 0.211 | 0.659 | 0.569 | 0.146 | 0.169 | 0.303 | 0.400 | 0.002 | -0.049 | 0.562 | 0.505 |
Representation 12Ă… | 0.213 | 0.276 | 0.608 | 0.281 | 0.162 | 0.188 | 0.447 | 0.846 | 0.043 | -0.031 | 0.584 | 0.492 |
Other methods | ||||||||||||
Daberdaku et. al. | 0.121 | 0.103 | 0.662 | 0.115 | 0.073 | 0.057 | 0.558 | 0.968 | 0.093 | 0.024 | 0.659 | 0.626 |
SPPIDER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.691 | 0.667 |
NPS-HomPPI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.712 | 0.642 |
PrISE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.655 | 0.642 |
 | OX class—receptors | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
F1 | Accuracy | Precision | Recall | MCC | AUC-ROC | |||||||
HSS-PPI | ||||||||||||
Residue Sequence | 0.213 | 0.208 | 0.219 | 0.264 | 0.12459 | 0.120 | 0.939 | 0.901 | 0.051 | 0.055 | 0.583 | 0.594 |
Contact Map 6 Ă… | 0.218 | 0.220 | 0.268 | 0.414 | 0.128 | 0.140 | 0.926 | 0.759 | 0.064 | 0.082 | 0.632 | 0.619 |
Contact Map 8 Ă… | 0.226 | 0.198 | 0.345 | 0.437 | 0.137 | 0.169 | 0.858 | 0.710 | 0.091 | 0.073 | 0.643 | 0.630 |
Contact Map 10 Ă… | 0.227 | 0.186 | 0.390 | 0.420 | 0.139 | 0.111 | 0.814 | 0.707 | 0.090 | 0.045 | 0.636 | 0.627 |
Contact Map 12 Ă… | 0.227 | 0.181 | 0.440 | 0.443 | 0.141 | 0.108 | 0.752 | 0.654 | 0.089 | 0.033 | 0.622 | 0.619 |
Hierarchical Representation 6Ă… | 0.216 | 0.201 | 0.249 | 0.167 | 0.126 | 0.115 | 0.928 | 0.965 | 0.056 | 0.025 | 0.614 | 0.601 |
Hierarchical Representation 8Ă… | 0.218 | 0.215 | 0.272 | 0.328 | 0.128 | 0.127 | 0.921 | 0.854 | 0.063 | 0.066 | 0.620 | 0.604 |
Hierarchical Representation 10Ă… | 0.219 | 0.209 | 0.272 | 0.425 | 0.128 | 0.137 | 0.913 | 0.706 | 0.058 | 0.050 | 0.612 | 0.606 |
Hierarchical Representation 12Ă… | 0.215 | 0.187 | 0.280 | 0.499 | 0.126 | 0.164 | 0.880 | 0.572 | 0.043 | 0.042 | 0.603 | 0.605 |
Other methods | ||||||||||||
Daberdaku et. al. | 0.108 | 0.081 | 0.677 | 0.670 | 0.063 | 0.045 | 0.555 | 0.490 | 0.089 | 0.056 | 0.665 | 0.614 |
SPPIDER | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.667 | 0.640 |
NPS-HomPPI | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.612 | 0.635 |
PrISE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.641 | 0.592 |