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Fig. 2 | BMC Bioinformatics

Fig. 2

From: CAISC: A software to integrate copy number variations and single nucleotide mutations for genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing

Fig. 2

Concordance between clustering with SNV and CNV profiles. A Distances between cells were calculated by their CNV profiles and grouped by SNV profiles for datasets GSE73122, P4 of GSE99095, MGH28-29 of GSE57872, and MGH30-31 of GSE57872. Smaller distances within cells in the same SNV identified clone indicate that cells with the same mutation types share similar CNV profiles. Distances among all cells are larger than those among cells grouped by SNV profiles, which is consistent with the hypothesis that there is co-occurrence between SNVs and CNVs in some clones (Additional file 1: Fig. S1). B The tanglegram compares the phylogenetic clustering based on SNV and CNV profiles. Cells in clones defined by SNV also appear in the same clones defined by CNV (MGH28-29 of GSE57872). The cophenetic correlation between the two clustering results is 0.80

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BMC Bioinformatics

ISSN: 1471-2105

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