Fig. 3

Cancer mutational signature analysis. We used the CANCERSIGN tool to identify mutational signatures in each subtype. Using CANCERSIGN and WGS somatic mutation form the CRC samples, we identified seven mutational signatures where were very similar with those identified by Alexandrov et al. [21] except the signatures 1 and 3 that the linear combination of them can represent the signature 10 COSMIC (Alexandrov et al.). The exposure matrix for identified signatures are also provided as the Additional file 1: Table S11. The evaluation plot of deciphering 3-mer mutational signatures also provided in Additional file 2: Figure S11