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Table 8 Comparison of accuracy as measured by F-measure for KnotAli with RNAalifold, Hxmatch, and Cacofold when compatible bases are not considered as false positive

From: KnotAli: informed energy minimization through the use of evolutionary information

Family

MUSCLE

MAFFT

KnotAli

RNAalifold

Hxmatch

Cacofold

KnotAli

RNAalifold

Hxmatch

Cacofold

5s

.920

.840

.581

.886

.922

.765

.550

.832

16s

.560

.635

.527

.267

.593

.677

.588

.297

23s

.639

.851

.652

.318

.401

.851

.657

.314

Group I intron

.549

.087

.065

.079

.474

.069

.068

.093

Group II intron

.205

0

.018

0

.431

.189

.182

.186

RNaseP

.547

.341

.225

.255

.645

.322

.123

.415

SRP

.620

.250

.250

.264

.463

.135

.135

.218

Telomerase

.336

.610

.430

.479

.278

.325

.361

.533

tmRNA

.556

.395

.294

.372

.578

.319

.087

.373

tRNA

.961

.951

.854

.926

.917

.858

.760

.885

  1. BOLD represents the significantly highest accuracy compared to others
  2. Each column represents the aligner used and each subcolumn represents F-measure value for one of the algorithms compared in this work