Fig. 4

Family-specific moieties and moiety interacting preferences of the EGFR and Akt family inhibitors. a Nine EGFR-family specific moieties, the interaction residue M793 and three EGFR family inhibitors shown by bound structures (PDB codes: 4G5J, 4I24, and 4LQM as well as their bound ligands 0WN, 1C9, and DJK respectively). b Six Akt-family specific moieties and interacting residues like E228 with of three Akt family inhibitor bound structures (PDB codes: 4GV1, 2XH5, and 4LQM as well as their bound ligands 0XZ, X37, and SMY respectively)