Fig. 5

Variant calling with different mutational signatures. A An example dynamics of the number of cells for each subpopulation generated during the simulation. The bottom part of the panel presents the input driver mutational tree with the birth rate for each subpopulation. B At the top we present the phylogenetic tree generated by sampling 100 cells. We proceeded by simulating three different substitution models generated combinations of signatures SBS6 and SBS22 from the COSMIC database [71]. The difference between the three models consists in the time dynamics of the activation functions presented in this figure. C The count of the number of unique mutations simulated divided per class of substitution. The plot presents the result for the three different models. D The count of the number of unique mutations divided per class of substitution detected using the pipeline described in the main text