Fig. 6

Immune simulation with vaccine construct. a Generation of antibodies after two doses of vaccine. The different isotypes and combinations of antibodies are shown in coloured peaks and antigen in black. b B-cell response after vaccine doses with coloured peaks denoting various subsets of B-cells. c Memory T-Helper cells and Total T-Helper cell proliferation curve. d Active and resting T-Helper cell population after vaccine injection. Resting T-cells are those which have not encountered the antigen and anergic cells signifies the T-cells which are tolerant to antigens e Active and resting Cytotoxic T-cell proliferation after vaccine dose. f The various cytokine profiles shown in coloured peaks with prominent up-regulation of pro-inflammatory IFN-γ (shown in violet). The insert graph shows simpson index D of IL-2 where D is measure of diversity