Table 2 HTL Epitopes shortlisted for Vaccine construction
From: In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani
Sl. No | Protein ID | Selected Epitopes | IEDB Percentile Rank | SMM Align IC50 | Vaxijen Score | Binding Alleles# | IFN- Pred Score | IL-10 Induction |
|---|---|---|---|---|---|---|---|---|
1 | XP_003863163 | EIKEAVLYENYLQVY | 0.32 | 18 | 1.037 | HLA-DPA1*0201-DPB1*0101, HLA-DPA1*0103-DPB1*0201, HLA-DPA1*0103-DPB1*0401, HLA-DPA1*0301-DPB1*0402, HLA-DPA1*0201-DPB1*0501 DRB1*1501, DRB1*1201, DRB1*1302, HLA-DQA1*0501-DQB1*0201, HLA-DQA1*0101-DQB1*0501 | 0.108 | X |
2 | XP_003865788 | MRPPFAVTIFVELLQ | 0.08 | 10 | 1.312 | HLA-DPA1*0201-DPB1*0101, HLA-DPA1*0103-DPB1*0401, HLA-DQA1*0401-DQB1*0402, HLA-DQA1*0301-DQB1*0302, HLA-DPA1*0103-DPB1*0201, HLA-DPA1*0301-DPB1*0402, HLA-DPA1*0201-DPB1*1401. | 0.180 | X |
YVRLIRGNPVKTANG | 0.70 | 49 | 1.039 | DRB1*0101, DRB1*1302, DRB1*1501, DRB1*0401 DRB1*0701, DRB1*0802, DRB1*0901, DRB1*1101, DRB1*1201, DRB3*0202, DRB4*0101, HLA-DQA1*0501-DQB1*0301, HLA-DQA1*0102-DQB1*0602 | 0.361 | X | ||
3 | XP_003857936 | CRRLRLAQSRRRAAQ | 0.02 | 4 | 0.918 | DRB1*0301, DRB1*1101, DRB4*0101, DRB5*0101, DRB1*0101, DRB1*0405, DRB1*0901, DRB3*0202 | 0.386 | X |
LFVWAVGGAAGGLCC | 0.31 | 8 | 0.825 | HLA-DQA1*0501-DQB1*0301, DRB1*0101, DRB1*0901 | 0.479 | X | ||
4 | XP_003864424 | ASSPFSSTRSSSSSR | 0.93 | 17 | 0.762 | DRB1*0405, DRB1*0401, DRB1*0701. | 0.626 | X |